SOX2 and cancer: Immunopositivity for Sox2 has been documented in examples of various other cancers including, but not limited to, lung adenocarcinoma (Nakatsugawa et al. 2011), melanoma (Girouard et al. 2012), breast carcinomas (Leis et al. 2012), and prostate carcinoma (Mimeault and Batra 2011).