SOX2 and metastatic carcinoma: Similarly, Sox2 IHC of 25 metastatic carcinoma and 10 metastatic melanomas in brain showed the same pattern, except that 16 and 2 cases of carcinoma and melanoma, respectively, had abundant Sox2-immunopositive tumor cells, consistent with previous literature (Basu-Roy et al. 2011; Girouard et al. 2012; Mimeault and Batra 2011; Nakatsugawa et al. 2011) (not shown).