SOX2 and glioma: Sox2 has been implicated in the oncogenesis of glial neoplasms in the brain (Alonso et al. 2011; Annovazzi et al. 2011; Guo et al. 2011; Schmitz et al. 2007), and has also been detected in cells of epithelial and mesenchymal tumors (Basu-Roy et al. 2011; Girouard et al. 2012; Mimeault and Batra 2011; Nakatsugawa et al. 2011), but is also a marker of neural stem cells where its function appears to be maintenance of pluripotency (Pevny and Nicolis 2010).