Impairment of axonal transport of mitochondria is an early event in mice overexpressing ALS-linked mutant forms of SOD1 or wild-type and mutant TDP43, all mimicking, to different degrees, the disease (De Vos et al., 2007; Wang et al., 2013; Magrané et al., 2014). The gene discussed is SOD1; the disease is amyotrophic lateral sclerosis.