CHCHD10 and amyotrophic lateral sclerosis: Although further analysis in larger populations is needed to confirm the frequency of these mutations in the familial/sporadic ALS population, and to make the genetic link between CHCHD10 and ALS more robust (van Rheenen et al., 2014), these findings might represent a landmark discovery in ALS research, because for the first time a gene coding for a mitochondrial protein has been identified as a possible cause for the disease, which eventually implies mitochondrial dysfunction as a primary trigger of ALS.