Further, three novel mutations (R15L, P34S and G66V) were identified in patients with ALS/FTD or ALS only, which strengthened the connection between CHCHD10 mutations and these diseases (Chaussenot et al., 2014; Johnson et al., 2014; Müller et al., 2014). Here, CHCHD10 is linked to amyotrophic lateral sclerosis.