2003)) than that used in this study or in Vietor et al. (1996) (5 IU/kg). These treatments can deplete epinephrine content by as much as 70% (Vollmer et al. 1992), indicating that not only the frequency of hypoglycemia exposure, but also the dose of insulin may be critical factors in the pathophysiology of HAAF. This evidence concerns the gene INS and Hypoglycemia.