The HPV 6, 16, and 18 E7 proteins of a high-risk human papillomavirus (HPV) involved in cervical cancer directly interact with PCAF (4) and the cellular protein AMF-1 (Gps2) positively modulates gene expression by the papillomavirus E2 protein via direct interaction with p300 (43). This evidence concerns the gene KAT2B and cervical carcinoma.