Although the CXCL8 promoter does not contain a CpG island and is therefore an unlikely candidate for DNA methylation analysis, dysregulated methylation of individual CpG sites within the CXCL8 promoter has been described in non-small cell lung cancer (51) and colorectal adenocarcinoma (16) and associated with altered gene expression. The gene discussed is CXCL8; the disease is colorectal adenocarcinoma.