In the context of cancer biology, only a limited number of Kaiso target genes have been identified thus far, including the matrix metalloproteinase matrilysin (MMP7) (Daniel et al., 2002), metastasis-associated gene 2 (MTA2) (Yoon et al., 2003), cyclin D1 (CCND1) (Park et al., 2005) and Wnt11 (WNT11) (Kim et al., 2004). The gene discussed is MMP7; the disease is cancer.