Although in normal epithelium p120 controls stability of the AJ through binding and stabilization of E-cadherin (Davis et al., 2003; Ireton et al., 2002; Nanes et al., 2012), loss of E-cadherin leads to translocation of p120 to the cytosol where it acts as an oncogene by regulating anchorage-independent tumor growth and metastasis through GTPase-dependent induction of resistance to anoikis (apoptosis that is induced through loss of cell-matrix adhesion) (Dohn et al., 2009; Schackmann et al., 2011; Soto et al., 2008). The gene discussed is CDH1; the disease is neoplasm.