CDH1 and invasive lobular breast carcinoma: In breast cancer, somatic inactivation of E-cadherin has been causally linked to the development and progression of invasive lobular carcinoma (ILC), a main breast cancer subtype comprising ~15% of all breast cancers (Berx et al., 1995; Derksen et al., 2006; Derksen et al., 2011).