We therefore decided to utilize the EphA3-null mice to test the effect of constitutive loss of EphA3 on lung ADC progression driven by mutant Kras (LSL-KrasG12D/+) (Jackson et al., 2001) and loss of Trp53 (p53fl/fl) (Marino et al., 2000), hereafter referred to as Kras and p53. Our data shows that the constitutive loss of EphA3 does not alter the progression of murine ADC in either of these models. Here, KRAS is linked to AIDS dementia complex.