Genetically engineered mouse models (GEMMs) are the most widely applied and functionally validated in vivo models of human lung cancer, in particular to validate gene cooperation concomitant with conditional expression of the oncogenic Kras gene (Jackson et al., 2001; Jackson et al., 2005; Ji et al., 2007; Schramek et al., 2011; Snyder et al., 2013). This evidence concerns the gene KRAS and lung cancer.