BRCA2 and undifferentiated (embryonal) sarcoma: Here we present the case of a 23 year old Caucasian patient with recurrent undifferentiated sarcoma, where tumor profiling reported pathogenic alterations in BRCA2 and MLH1. Constitutional analysis confirmed a pathogenic BRCA2 alteration and led to reclassification of the MLH1 alteration as a variant of uncertain significance.