NF2 and neoplasm: Several proteins can act upstream of the core kinase cascade, including the apical FERM-domain proteins Expanded (Ex; similar to both FRMD6 and AMOT proteins in humans) and Merlin (Mer; the NF2 tumour suppressor in humans), which act in parallel with activate Hippo signalling (Hamaratoglu et al, 2006; Irvine, 2012).