LATS1 and neoplasm: The different reasons might be analysed as follows: on the one hand, our study showed that LATS1 functioned as a tumour suppressor in LAC cells and 17-AAG activated the LATS1 expression and then suppressed the phosphorylation of YAP, exerting the anti-LAC effects; On the other hand, we indirectly indicated that the LATS1 kinase might not be the bona fide HSP90 client and 17-AAG served as the activator of the LATS1 kinase in LAC cells.