It is found that LATS1/2 may be the HSP90 clients in several tumour cell lines including LAC A549, and 17-AAG contributes to the depletion and reduced LATS1/2 levels, leading to decreased phosphorylation of YAP and enhanced expression of connective tissue growth factor (CTGF) 21. The gene discussed is LATS1; the disease is neoplasm.