VIP and arthritic joint disease: Treatment with VIP has been shown to reduce the severity of arthritis in murine models (Delgado et al. 2001; Juarranz et al. 2005) and improves the course of other inflammatory models in mice (Abad et al. 2003; Jimeno et al. 2010; Li et al. 2006; Lodde et al. 2006).