As we previously reported, HMGA1 plays an essential role in the transcriptional regulation of these two genes2, 23, and individuals with defects in HMGA1 have increased susceptibility to type 2 diabetes mellitus3, 17, 39, 40 and metabolic syndrome41, a cluster of individual disorders all predisposing to cardiovascular disease. This evidence concerns the gene HMGA1 and cardiovascular disorder.