In molecular features, the APC gene mutations present in the early phase of colorectal cancer formation with approximately 70% of colorectal adenoma.[67] Furthermore, activating mutations of the KRAS oncogene and inactivating mutations of the TP53 tumor suppressor gene could promote adenoma–carcinoma sequence.[68] However, in the present study, whether the shorter latent period for colorectal cancer after appendectomy is attributable to molecular changes after removing appendix is unclear. Here, TP53 is linked to colorectal adenoma.