In molecular features, the APC gene mutations present in the early phase of colorectal cancer formation with approximately 70% of colorectal adenoma.[67] Furthermore, activating mutations of the KRAS oncogene and inactivating mutations of the TP53 tumor suppressor gene could promote adenoma–carcinoma sequence.[68] However, in the present study, whether the shorter latent period for colorectal cancer after appendectomy is attributable to molecular changes after removing appendix is unclear. This evidence concerns the gene APC and colorectal adenoma.