Notably, several mutations both in the CCPs as well as in the transmembrane region are linked to atypical hemolytic uremic syndrome (aHUS) [21,22].While we initiated our studies on the AP regulatory genes in preeclampsia, MCP among other complement regulators received considerable attention as potential target for mutations in preeclampsia [12]. Here, DHCR7-DT is linked to atypical hemolytic-uremic syndrome.