Given the large changes in Oat2 expression, the inhibitory potential of metabolites (adipate, suberate, glycolate, citrate, 3-hydroxyisobutyrate, cis-aconitate, and homovanillate) associated with diabetic kidney disease [26, 27], drugs for treatment of diabetes (sitagliptin, miglitol), and hypertension (captopril, enalapril, furosemide, and bumetanide) on human OAT2 expressed in HEK293 cells was investigated. This evidence concerns the gene SLC22A7 and Hypertension.