Iron available for erythropoiesis is reduced due to increased proinflammatory cytokines (functional iron deficiency), which decrease ferroportin (release of iron from macrophages) and increase hepcidin (which blocks duodenal iron absorption) and the divalent metal transporter (able to bind and transport divalent metals along the plasmatic membranes) [19]. The gene discussed is HAMP; the disease is Iron deficiency anemia.