Figure 7(b) shows that the mRNA and protein expressions of IRF3 were significantly decreased in the model group compared to the virus group (P < 0.01, P < 0.05), and the expression of NF-κB p65 was increased significantly (P < 0.01). Administration of vitamin C significantly increased the expression of IRF3 and decreased the expression of NF-κB p65 in influenza infected mice loaded with restraint stress (P < 0.05, P < 0.01). Here, IRF3 is linked to influenza.