AKT1 and heart failure: Moreover, among the most regulated pathways by the subset of miRNAs identified in the presented analysis, PI3K-Akt and mTOR signaling pathways can also be importantly involved in mechanisms controlling the progression of heart failure [42], while the Wnt signaling pathway, normally regulating cardiogenesis during the development, can be induced in adult heart during maladaptive myocardial remodeling [43].