In addition, depletion of Ca2+ from the ER may drive tumor growth by inducing Ca2+ influx through the plasma membrane, as the expression of the SOCE canonical components STIM1 and ORAI1 is augmented in various cancer types, including breast cancer, glioblastoma, melanoma, and esophageal carcinoma (reviewed in [1, 14]). This evidence concerns the gene STIM1 and melanoma.