Considering that P2XRs have been widely related to epilepsy [85] as well as TNAP is able to regulate ligand availability (ATP) in the environment of P2XRs, together with recently reported work where it is described that PLP can antagonize the response induced by the activation of some P2XRs [86], we can suggest that the contribution of TNAP to the seizures suffered by TNAP null mice may be due to multiple factors. The gene discussed is ALPL; the disease is epilepsy.