AKT1 and neoplasm: NFV is an HIV aspartyl protease inhibitor that, in addition to its antiretroviral activity, has complex effects on numerous human cellular functions, including on Akt signaling, inhibition of cellular proteases, and induction of ER stress, many of which might contribute to its ability to broadly inhibit tumor cell growth as well as replication of several non-HIV viruses [9, 11, 16, 17, 35, 36].