Thus, an inflammation model of dextran sodium sulfate (DSS)-induced chronic colitis revealed more leukocyte infiltration in the gut and a more severe colitis phenotype in endoglin heterozygous (Eng+/-) mice relative to control animals (Jerkic et al., 2010; Ardelean et al., 2014; Peter et al., 2014). Here, ENG is linked to colitis.