ENG and myocardial infarction: After myocardial infarction, a greater deterioration in cardiac function was observed in Eng+/- compared to control mice, although host inflammatory leukocyte numbers in the infarct zone were similar; however, defects in vessel formation and heart function in Eng+/- mice were rescued by injection of leukocytes from healthy human donors, but not by leukocytes from HHT1 patients (van Laake et al., 2006).