CD274 and neoplasm: As will other immune-related parameters, such as the activation state of TILs, expression of immune-inhibitory proteins (B7-H1/PD-L1, IDO, Arginase), changes in endothelial homing receptor ligands and tumor-associated chemokines, the presence of immune/inflammatory expression patterns, the presence of tissue-specific destruction and IFN-gamma upregulation, and in vitro determination of tumor cell lysis in comparison to allogeneic tumor cells.