CTLA4 and melanoma: The approval of oncogene-targeted drugs such as vemurafenib and dabrafenib for BRAFV600 mutated melanoma (3, 4), and of monoclonal antibodies (mAbs) targeting immunomodulatory molecules such as ipilimumab for CTLA-4 (5) and pembrolizumab for PD-1 (6), has dramatically changed the treatment of advanced melanoma in recent years.