CD4 and rheumatoid arthritis: All CD4+ Vδ1+ T-cell clone-derived αβT cells were T10B9.1A-31+ (framework epitope of αβTCR heterodimer), WT31+ (CD3ε), CD3+, Vδ1neg, γδTCRneg, CD25lo/neg, CD28neg, and were also terminally differentiated effector-memory RA-re-expressing T cells (TEMRA) (Figure 5B).