However, under septic conditions, Moldawer and colleagues found that a different response where CD11b+Gr-1+ MDSCs expanded in the spleen, in the bone marrow, and in the peripheral lymph nodes by 3 days after sepsis and several approaches to prevent the expansion of these cells deteriorated the immunosuppression and worsened outcomes [9, 10]. This evidence concerns the gene ITGAM and Sepsis.