TGFB1 and bone fracture: Lind et al. administered TGF-β1 and TGF-β2 with an osmotic minipump to adult rabbits with induced tibial bone fracture at a dose ranging from 1 to 10 μg for six weeks, and after the end of the experiment they observed an increased mechanical strength in the fracture site and increased callus formation versus the control group not receiving TGF-β [198].