DCT and neoplasm: However, mice treated with fibrin matrices functionalized with FNIII 11-EDA + FNIII 9-10 + TG-TRP-2173–188 showed a substantial reduction in the number of splenic MO-MDSCs, demonstrating the ability of the FNIII 11-EDA domain to induce local (delay of tumor growth) and systemic (reduction in splenic MO-MDSC numbers) immune responses to an endogenous antigen, here the melanocyte-specific antigen TRP-2.