Thus, using two tumor models, one with an exogenous model antigen and one with an endogenous antigen, N-terminally-extended FNIII EDA without C-terminal extension with the native FNIII 12-13-14 domain was shown to induce potent immunity as characterized by the cytotoxic functionality of induced CTLs when the FN domains were co-administered in a matrix with antigen. Here, FN1 is linked to neoplasm.