NFE2L2 and neurodegenerative disease: • A continuous dietary supply of high micronutrient food with the minimum xenobiotic load is the way of deferring degenerative diseases of all types. The development of ‘technology”, driven by the same cortico-limbic-striatal system, has skewed the food intake too far from the requirements of the NRF2 system. The two systems are no longer complimentary, with the former disrupting the function of the latter.