• In the module of miR-34a and miR-214, besides the confirmed miR-214 and its mRNA RAB43, miR-34a has been reported to upregulate in both liver fibrosis and hepatocellular carcinoma, and serum levels of miR-34a are significantly higher in chronic hepatitis C infection patients than in controls [31]. The gene discussed is RAB43; the disease is chronic hepatitis C virus infection.