The first we are aware of was a report in this journal in 1972, describing an Icelandic family with MDS/AML in association with trisomy 8 and Pelger-Huet abnormality (Kaur et al, 1972), subsequently traced two generations later to a GATA2 T354M mutation (Dickinson et al, 2014). Here, GATA2 is linked to acute myeloid leukemia.