The acquisition of additional genetic abnormalities in the transformation of GATA2 mutation to multilineage dysplasia is clearly presaged by the high incidence of monosomy 7 and trisomy 8 in familial cases of MDS/AML (Hahn et al, 2011; Ostergaard et al, 2011; Bodor et al, 2012; West et al, 2013; Dickinson et al, 2014; Micol & Abdel-Wahab, 2014; Spinner et al, 2014). Here, GATA2 is linked to acute myeloid leukemia.