PDRG1 and malignant colon neoplasm: It has been reported recently that PDRG1 expression was upregulated in multiple malignancies including cancers of the colon, rectum, ovary, lung, stomach, breast and uterus compared to their respective matched normal tissues and PDRG1 knockdown in human colon cancer cells resulted in marked slowdown of tumor cell growth [38], which is in line with our findings.