Examples of known enhancers that displayed DNA methylation changes in these clusters include the tumor-specific hypomethylation of the distal enhancer of MYC (C-5 HMR) that is 67 Kb upstream of the TSS [47], and the hypermethylation of the enhancer in the second intron of NOTCH1 (A-7 HMR) [48] (S9A and B Fig). Here, NOTCH1 is linked to neoplasm.