Pancreatic β-cells are particularly susceptible to damage by oxidative stress when exposed to chronic hyperglycemia [3] because they are low in free-radical quenching enzymes.[4] Further, ROS can suppress the insulin response and contribute to the development of insulin resistance, a key pathological feature of type 2 DM.[5] Therefore, adequate glycemic control is essential for preventing complications associated with type 2 diabetes. Here, INS is linked to type 2 diabetes mellitus.