The primary reason which makes HA an ideal choice for cancer intervention is that two HA receptors, the hyaluronan receptor CD44 and the receptor for hyaluronic acid-mediated motility (RHAMM or CD168), are strongly implicated in cancer cell signaling[88,89].In addition, HA interacts with intracellular adhesion molecule-1 (ICAM-1), toll-like receptor-4 (TLR-4), hyaluronan receptor for endocytosis (HARE), and lymphatic vessel endocytic receptor-1 (LYVE-1) [90,91,92,93]. This evidence concerns the gene CD44 and cancer.