The kinases inhibition may contribute, at least to some extent, to the cytotoxic and pro-apoptotic properties of lamellarin N. This work opened the way for the design of lamellarin-derived kinases inhibitors, such as chromeno[3,4-b]indoles developed as lamellarin isosteres and for which two lead compounds were identified as nanomolar inhibitors a the kinase DYRK1A (dual-specificity tyrosine-(Y)-phosphorylation-regulated kinase 1A), that is a potential drug target for neurodegenerative diseases and cancer [67]. This evidence concerns the gene DYRK1A and neurodegenerative disease.