In this report, we confirmed that rescuing the number of copies of Abcg1-U2af1 modulates Tc1-induced phenotypes only slightly, although the region was sufficient alone to induce certain learning and memory deficits [15,16], and as such this genetic interval certainly contributes, along with other regions of Hsa21, to the variability of DS features. The gene discussed is ABCG1; the disease is Dravet syndrome.