It is clear that the levels of S100A8 and S100A9 are increased in a range of different lung disorders, but to date, no standardized methods for the collection, detection or reporting of S100A8, S100A9 or S100A8/A9 levels from clinical samples from the lung have been established to allow direct comparisons to be made. The gene discussed is IGKV1D-22; the disease is lung disorder.