We also demonstrated that blockade of IL-1β with neutralizing antibodies can reduce the formation of melanoma nodules (Fig. 4B, black bars) and lower MDSCs accumulation (Fig. 5) in lung tissues in DJ-1 KO mice, suggesting that DJ-1 loss-induced MDSCs accumulation and tumor development in lungs are IL-1β dependent. This evidence concerns the gene IL1B and melanoma.