In the contrary, blockade of IL-1β by injecting with neutralizing antibodies antagonized the nodule formation in DJ-1 KO mice (black bars in Fig. 4B), indicating that IL-1β signaling is involved in the DJ-1 deficiency-enhanced migration of cancer cells to lungs (n = 5 for each group, F = 44.622, P < 0.05). The gene discussed is IL1B; the disease is cancer.