CDH1 and cancer: To address the precise mechanism(s) for SATB1-induced EMT-like phenotypic changes in cancer cells, researchers established several experimental cell models, finding that overexpression of SATB1 could induce EMT in non-aggressive tumor cells, while SATB1 depletion could reverse EMT in aggressive tumor cells by regulating Snail, Slug and E-cadherin in vitro[24].