By examining a cohort of 95 CRC patients’ tissues and their adjacent normal tissues (ANT), we have obtained three major findings: (1) HPV infection exists in almost a half of CRC cases, of which 97.8% are infected with high-risk HPV16 type; (2) HPV infection correlates with poorer clinical stages of CRC; and (3) HPV infection strongly correlates with constitutive activities of Stat3 and its downstream IL-17 levels in CRC tissues. This evidence concerns the gene STAT3 and colorectal carcinoma.