A total of 6950 patients were included in the 27 studies, among which 24 (5130 cases) estimated the association of fusion of the EML4-ALK gene in NSCLC with a history of smoking; while 17 studies emphasized the association of the EML4-ALK rearrangement to tissue types (3360 cases); 13 papers reflected the relation of the EML4-ALK fusion gene to clinical stages (2876 cases) and 26 researches showed the association of this fusion gene and the gender of patients (5797 cases). This evidence concerns the gene EML4 and non-small cell lung carcinoma.