Multivariate-adjusted TR of MetS was 0.12 (95% CI 0.02–0.78; P = 0.03) in subjects with total adiponectin level of 5.0–6.6 μg/ml, and 0.15 (95% CI 0.02–0.97; P = 0.047) in subjects with total adiponectin level ≤ 4.9 μg/ml compared with that in subjects with total adiponectin level ≥ 8.9 μg/ml. This evidence concerns the gene ADIPOQ and metabolic syndrome.