The mean time to the development of MetS was 78% shorter in subjects with total adiponectin level ≤ 6.2 μg/ml compared with > 6.2 μg/ml; that is, subjects with total adiponectin level ≤ 6.2 μg/ml developed MetS more rapidly compared with those with total adiponectin level > 6.2 μg/ml. The gene discussed is ADIPOQ; the disease is metabolic syndrome.