Furthermore, in pediatric patients undergoing CPB, acetaminophen attenuated the increase in plasma isofuran concentrations but did not affect urinary makers of lipid peroxidation, serum concentrations of creatinine, or urine concentrations of neutrophil gelatinase-associated lipocalin (NGAL).[4] The effect of acetaminophen on oxidative damage in adults undergoing CPB is unknown and deserves further study since intraoperative oxidative damage independently predicts postoperative AKI[7] and 500,000 patients undergo cardiac surgery each year. The gene discussed is LCN2; the disease is acute kidney injury.