IRS2 and neoplasm: The transcriptomic profile of these epithelial cells showed cellular functions relating to cell adhesion (DST, RND3) [25,26], apoptosis (NR4A2, STK17B, miR-21) [27–29], airway dysplasia (ASCL1) [23], tumor suppression (MAP3k8) [30], angiogenesis (AMOTL2) [31], and signaling pathways, such as MAPK signaling (miR-483–5p, LDLR) [32,33], and PI3k-Akt (IRS2, miR-26a) [34,35].