Of the 64 mRNAs and 17 miRNAs significantly expressed in the contralateral peripheral airway, 10 mRNAs/miRNAs have similar up/down expression as that of lung adenocarcinoma tumors or lung adenocarcinoma cell lines; AHR (up), DPYD (up), ERV3–1 (up), LDLR (up), TUSC2 (down) miR-224 (down), miR-27b (down), miR-26a (down), miR-483–5p (up), and miR-210 (up) [54–61]. The gene discussed is DPYD; the disease is lung adenocarcinoma.