For example, it is interesting to note that there are mRNAs and miRNAs with opposite up/down expression compared to lung adenocarcinoma tumors / cell lines: AKIP1 (down in field of cancerization vs. up in lung adenocarcinoma), ASCL1 (down vs. up), miR-708 (down vs. up), miR-21 (down vs. up), and miR-31(down vs. up) [59,62–65]. The gene discussed is ASCL1; the disease is lung adenocarcinoma.