Premature ovarian failure (POF), also known as premature ovarian insufficiency, is characterized by amenorrhea for at least four to six months before the age of 40 with sex steroid deficiency and raised serum concentrations of follicle-stimulating hormone (FSH) of more than 40 IU/L occurring at least 1 month apart [1]. This evidence concerns the gene BRD2 and amenorrhea.