The key genes that were identified mediated crosstalk between the dysregulated pathways and included MAPK1 and RAF1, two factors in MAPK signaling that play important roles in the immune response [39], neurotransmission [67], and neurological diseases such as Alzheimer's disease and Parkinson's disease as well as amyotrophic lateral sclerosis [68]. This evidence concerns the gene RAF1 and early-onset autosomal dominant Alzheimer disease.