For this purpose, immunofluorescence analysis of IgM anti-TG2 deposits in the SB biopsy of 25 CD children with IgA deficiency, 12 untreated CD with normal IgA levels, 9 PCD with IgA deficiency, and 16 healthy controls was described by Borrelli et al. Intestinal IgM deposits were more prevalent in subjects with CD compared to PCD, but did not discriminate accurately CD from PCD in this group with IgA deficiency (29). Here, CD40LG is linked to selective IgA deficiency disease.