In glioblastoma cells, miR-21 targets genes that are involved in the major cancer suppression pathways: in p53 pathway (JMY, TOPORS, IGFBP3, TP53PP2, DAXX, HNRPK, and TP73L), in TGF-β pathway (TGFFBR2/3, BHPK2, and DAXX), in mitochondrial apoptotic pathway (APAF1 and PPIF) [23]. Here, DAXX is linked to glioblastoma.