In particular, the ability of Tat to increase the expression of interleukins-6 (IL-6) and 10 (IL-10) [25, 26], which in turn promote B-cell stimulation, and the evidence that about 30% of Tat-transgenic mice develop B-cell lymphomas [27], suggest that Tat might play a role in the pathogenesis of HIV-related B-lymphomas. Here, TAT is linked to B-cell non-Hodgkin lymphoma.