KCNMA1 and Generalized epilepsy - paroxysmal dyskinesia: Interestingly, D369G, the human hereditary mutation associated with generalized epilepsy and paroxysmal dyskinesia (GEPD) (Du et al., 2005), enhances BK channel Ca2+ sensitivity specifically through the RCK1 site but not the Ca2+ bowl (Yang et al., 2010).