In genetic association studies, IL-1 or IL-1Ra gene polymorphisms are associated with increased susceptibility to stroke, atherosclerosis and ICH in humans (Seripa et al., 2003; Um et al., 2003; Worrall et al., 2003; Dziedzic et al., 2005; Rezaii et al., 2009). This evidence concerns the gene IL1A and stroke disorder.